The Isabella was built at Shoreham, Sussex, on the coast of England, in 1825. She weighed 194 tons and measured 84 feet.

The ship had several owners before it was purchased by the Hudson's Bay Co. which was attempting to make up for revenue lost when the William and Ann was lost in 1829.

The following appeared excerpt was taken from Jim Delgado's 1996 article in The American Neptune Vol. 55, No. 4. Delgado cites the Isabella's logbook.

"At 2:30 a.m. o May 2, The coast was sighted, and at 4:30 [Capt. William] Ryan shortened sail to single reef topsails. By noon, Cape Disappointment bore northeast by east, and throughout the day and into the evening, Isabella approached the Columbia River Bar. Captain Ryan made a critical mistake as he entered; thinking that Chinook Point was actually Cape Disappointment. Bearing too far south, he missed the channel.

"At 4:00 am on May 3, Isabella crossed the bar, which was marked by 'a very great swell and broken water ahead...' Outside of the channel, the brig struck. The rudder tore free and the Isabella broached to with her head to the north, "unmanageable in the heavy sea and strong flood tide."

"A broken piece of the rudder remained attached to the sternpost; with this fragment and by trimming the sails, Ryan and the crew tried to work the brig out of danger.

"Pounding on the sand bottom in fifteen feet of water, Isabella was in peril. The larbord bower anchor was let go, and the crew "got the boats out, stove the water casks upon deck and cleared away the lumber.

"Vessel still striking very heavy we hove a great deal of the cargo and stores overboard, about thirty tons of stores and cargo and the vessel still continuing to strike hard, there appeared little prospect of saving her and being surrounded by heavy breakers fearing she would drive on shore into them when it would be impossible to save our selves,

Ryan ordered Isabella abandoned at half past 8 p.m. The crew took to the brig's boats, impelled not only by the possibility of shipwreck, but also the tales that William and Ann's crew had been massacred by the Clatsop people after that brig's loss."

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